Heterocyclic acetic acid derivatives and a process for the...

C - Chemistry – Metallurgy – 07 – D

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260/335.5, 260/3

C07D 205/08 (2006.01) C07D 207/277 (2006.01) C07D 405/04 (2006.01)

Patent

CA 1189866

ABSTRACT OF THE DISCLOSURE New compounds of the general formula (I), (I) Image wherein y1 and y2 form together a removable carbonyl protect- ing group and X is a selectively removable esterifying group, are prepared in the way that a compound of the general formula (IV) Image (IV) wherein y1 and y2 are as defined above, is nitrated and then reduced, the resulting compound of the general for- mula (III), wherein - 2 - Image (III) y1 and y2 are as defined above and A stands for nitro group and then for amino group, is converted into an ester of the general formula (II), wherein y1, y2 and X are as defined above, (II) Image and the aminophenyl protecting group of the resulting compound is split off. The new compounds of ths general formula (I) can be applied primarily as intermediats in the synthesis of thienamycin or thieuamycin analogues.

418740

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