Heterocyclic antiviral compounds

Details Heterocyclic antiviral compounds Heterocyclic antiviral compounds

C - Chemistry, Metallurgy

07

D

C07D 498/10 (2006.01) A61K 31/537 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2682639

This invention relates to piperidine derivatives of formula (I) wherein R1, R2, R3 and R4 are as defined herein useful in the treatment of a variety of disorders, including those in which the modulation of CCR5 receptors is implicated. Disorders that may be treated or prevented by the present derivatives include HIV and genetically related retroviral infections (and the resulting acquired immune deficiency syndrome, AIDS), rheumatoid arthritis, solid organ transplant reject (graft vs. host disease), asthma and COPD.

Cette invention porte sur des dérivés de pipéridine de formule (I) dans laquelle R1, R2, R3 et R4 sont tels que définis présentement, utiles dans le traitement d'une diversité de troubles, comprenant ceux dans lesquels la modulation de récepteurs de CCR5 est impliquée. Les troubles qui peuvent être traités ou prévenus par les présents dérivés comprennent les infections par le VIH et les rétrovirus génétiquement apparentés (et le syndrome d'immunodéficience acquise résultant, SIDA), l'arthrite rhumatoïde, le rejet de greffe d'organe solide (réaction du greffon contre l'hôte), l'asthme et la bronchopneumopathie chronique obstructive (COPD).

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