C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/41 (2006.01) A61K 31/4178 (2006.01) A61K 31/4439 (2006.01) A61K 31/5377 (2006.01) A61P 3/04 (2006.01) A61P 5/08 (2006.01) A61P 5/48 (2006.01) A61P 19/10 (2006.01) C07D 257/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2367461
Heterocyclic aromatic compounds are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. The heterocyclic aromatic compounds have structure (I) including pharmaceutically acceptable salts thereof and all stereoisomers thereof, wherein Xa is heteroaryl, preferably (a), (b) or (c) and R1, R1a, R6, Y, Xb, A, B, Z, R3, R4, R4a, R5 and R5a are as defined herein.
L'invention concerne des composés hétérocycliques aromatiques utilisés pour stimuler la production ou la libération endogène d'hormones de croissance et pour traiter l'obésité, l'ostéoporose (amélioration de la densité osseuse) et pour améliorer la masse musculaire et la force musculaire. Les composés hétérocycliques aromatiques présentent la structure (I) comprenant des sels pharmaceutiquement acceptables et tous les stéréoisomères dans laquelle X¿a? représente un hétéroaryle, de préférence (a), (b) ou (c) et R¿1?, R¿1a?, R¿6?, Y, X¿b?, A, B, Z, R¿3?, R¿4?, R¿4a?, R¿5? et R¿5a? sont tels que définis dans le descriptif.
Hernandez Andres S.
Li James J.
Li Jun
Robl Jeffrey
Swartz Stephen G.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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