C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/233, 260/311
C07D 263/56 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) C07D 263/32 (2006.01) C07D 277/22 (2006.01) C07D 277/64 (2006.01)
Patent
CA 2026227
ABSTRACT OF THE DISCLOSURE: A novel heterocyclic compound represented by the following formula (I): Image (I) wherein X represents an oxygen atom or sulfur atom; R1 represents a hydrogen atom or halogen atom; R2 represents a C4-C6 alkyl group, C2- C10 alkoxyalkyl group, C3-C15 alkenyl group, C7-C12 aralkyl group, C8- C18 aralkyloxyalkyl group, C7-C12 aryloxyalkyl group, C3-C10 alkynyl group, C4-C12 alkadienyl group, C6-C18 alkatrienyl group, C6-C12 alkadiynyl group, or C6-C12 alkatriynyl group, said aryloxyalkyl group, alkynyl group, alkadienyl group, alkatrienyl group, alkadiynyl group and alkatriynyl group being capable of having at least one substituent selected from the group consisting of halogen atoms, C1-C4 alkyl group, C1-C4 halogenated alkyl group, phenyl group, hydroxyl group and C1- C4 alkoxy group; and each of R3 and R4 independently represents a hydrogen atom, C1-C6 alkyl group, phenyl group or tolyl group, or R3 and R4 may be combined together to from a benzene ring which may have at least one halogen atom; or a pharmaceutically acceptable salt thereof. The compound according to the present invention has an effect of inhibiting lipoxygenase and suppresses the formation of leukotrienes and, accordingly, useful for the prevention and treatment of inflammation, rheumatism and various allergic diseases. - 57 -
Hayashi Yoshio
Kadowaki Shuitiro
Ubasawa Masaru
Goudreau Gage Dubuc
Hayashi Yoshio
Kadowaki Shuitiro
Mitsubishi Chemical Corporation
Ubasawa Masaru
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