C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/200, 167/208
C07D 401/12 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 215/20 (2006.01) C07D 215/227 (2006.01) C07D 215/26 (2006.01) C07D 215/36 (2006.01) C07D 215/38 (2006.01) C07D 217/02 (2006.01) C07D 239/74 (2006.01) C07D 241/42 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)
Patent
CA 1340821
Novel heterocyclic compounds, which are represented by the following general formula, useful as anticancer drug potentiaters having a potentiating effect on the incorporation of anticancer drugs into cancer cells, the compounds each synthesized by, for example, reacting a epoxy compound obtained by reacting a heterocyclic compound with an epihalogenohydrin, with an amine derivative. Representative compounds are represented by the formula I (see formula I) wherein A may be O, B may be -(CH2)m-, C may be (see formula II) D may be (see formula III), E, F, G and H may each independently represent a carbon or nitrogen atom, provided at least one of them is nitrogen, R1 and R2 each independently represent a hydrogen or halogen atom, a C1-4 lower alkyl, amino group, substituted amino group, a C1-4 lower alkoxy, C1-4 lower alkylthio, C1-4 lower alkylsulfonyl, trifluoromethyl, cyano, nitro or amide group, wherein R1 and R2 may be on any position available on the condensed ring or one each on each of the rings or both on the same ring of which the condensed ring is formed; R3 represents a hydrogen atom or a C1-4 lower alkyl or acyl group; R4 represents a hydroxyl, C1-4 lower alkyl amino, C1-4 lower alkoxyl or C1-2 lower acyloxy group; R5 and R6 each independently represent a hydrogen atom or a C1-4 lower alkyl or hydroxyalkyl group; R7 represents hydrogen atom or hydroxy group, R8 and R9 each independently represent phenyl, pyridyl or substituted phenyl group; I represents an oxygen atom, (see formula IV) or a nitrogen atom; J represents - (CH2)m-, -CH=CH-, -OCH2- or an oxygen atom; n represents an integral number in the range between 1 and 10, and m represents an integral number, 0, 1 or 2, or a pharmaceutically acceptable salt thereof.
615404
Fukazawa Nobuyuki
Odate Makoto
Otsuka Kengo
Sato Wakao
Suzuki Tsuneji
Mitsui Toatsu Chemicals Incorporated
Schering Aktiengesellschaft
Sim & Mcburney
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