Heterocyclic compounds as pstat3/il-6 inhibitors

Details Heterocyclic compounds as pstat3/il-6 inhibitors Heterocyclic compounds as pstat3/il-6 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 209/88 (2006.01) A61K 31/403 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2625219

The present invention relates to novel heterocyclic compounds of the general formula (I), as IL-6 inhibitors, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly provides novel heterocyclic compounds of the general formula (I). Also included is a method for treatment of cancer, cancer cachexia and inflammatory diseases including immunological diseases, particularly those mediated by cytokines such as IL-6, through pSTAT3 inhibition, in a mammal comprising administering an effective amount of a compound of formula (I) as described above.

La présente invention a trait à de nouveaux composés hétérocycliques de formule générale (I), en tant qu'inhibiteurs de l'IL6, leurs dérivés, leurs analogues, leurs formes tautomériques, leurs stéréoisomères, leurs formes polymorphes, leurs hydrates, leurs solvates, leurs sels et compositions pharmaceutiquement acceptables, les métabolites et les prodrogues de ceux-ci. Plus particulièrement, la présente invention a trait à de nouveaux composés hétérocycliques de formule générale (I). L'invention a également trait à un procédé pour le traitement du cancer, de la cachexie cancéreuse et de maladies inflammatoires comprenant les maladies immunologiques, notamment celles liées par des cytokines telles que l'IL6 par l'inhibition de pSTAT3, chez un mammifère comprenant l'administration d'une quantité efficace d'un composé de formule (I) de l'invention.

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