C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/4709 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) C07D 401/08 (2006.01) C07D 401/14 (2006.01) C07D 413/08 (2006.01) C07D 413/14 (2006.01) C07D 487/08 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2521625
The present invention is directed to compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
L'invention concerne des composés de formule (I), dans laquelle R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n et la ligne pointillée sont tels que définis dans la description. Ces composés sont utilisés en tant que modulateurs de l'activité des récepteurs de chimiokine. Plus particulièrement, ces composés sont utiles en tant que modulateurs du récepteur CCR-2 de chimiokine.
Butora Gabor
Goble Stephen D.
Moyes Christopher R.
Pasternak Alexander
Yang Lihu
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Merck Sharp & Dohme Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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