C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61P 9/06 (2006.01) C07D 231/00 (2006.01) C07D 235/00 (2006.01) C07D 239/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2393809
Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v1 subfamily of voltage gated K+ channels, especially inhibitors K v1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current I Kur), methods of using such compounds in the prevention and treatment of arrhythmia and I Kur-associated conditions, and pharmaceutical compositions containing such compounds.
La présente invention concerne de nouveaux composés dihydropyrimidine hétérocyclique qui sont utiles en tant qu'inhibiteurs de la fonction des canaux potassium (plus particulièrement des inhibiteurs de la sous-famille Kv1 des canaux K<+> commandés par porte de tension, plus spécifiquement des inhibiteurs Kv1,5 qui ont été liés au courant IKur K<+> d'un redresseur retardé à activation ultra-rapide), des procédés d'utilisation de ces mêmes composés pour prévenir et traiter l'arythmie et des états associés à IKur ainsi que des compositions pharmaceutiques renfermant lesdits composés.
Atwal Karnail S.
Bhandaru Rao S.
Finlay Heather
Lloyd John
Vaccaro Wayne
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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