C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/44 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2413971
The invention relates to novel 2-benzimidazolyl-, 2-benzoxazolyl- and 2- benzothiazolyl hydrazones that are derived from 2-formylpyridine, 2- acylpyridines, acetyldiazines and acetyl(iso)quinolines. The invention also relates to a novel method for producing 2-benzimidazolyl-, 2-benzoxazolyl- and 2-benzothiazolyl hydrazones and to their use as useful anti-cancer therapeutic agents. The novel compounds are also active against multidrug-resistant cancer cells.
L'invention concerne des hydrazones 2-benzimidazolyle, 2-benzoxazolyle et 2-benzothiazolyle, qui dérivent de 2-formylpyridine, 2-acylpyridines, d'acétyldiazines et d'acétyle(iso)quinoléines. Elle concerne également un procédé de production d'hydrazones 2-benzimidazolyle, 2-benzoxazolyle et 2-benzothiazolyle et leur utilisation dans la thérapie de lutte contre le cancer. Ces composés sont en outre actifs contre les cellules cancéreuses résistantes à l'action de plusieurs médicaments.
Easmon Johnny
Fiebig Heinz-Herbert
Heinisch Gottfried
Hofmann Johann
Purstinger Gerhard
Austria Wirtschaftsservice Geselschaft Mit Beschrankter Haftung
Benoit & Cote Associes Inc.
Easmon Johnny
Fiebig Heinz Herbert
Heinisch Gottfried
LandOfFree
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