Heterocyclic mchr1 antagonists

Details Heterocyclic mchr1 antagonists Heterocyclic mchr1 antagonists

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4985 (2006.01) A61P 3/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2521832

This invention relates to novel heterocycles which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), also referred to as 11CBy, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in medicines. Compounds of the invention have formula (I).

L'invention concerne des dérivés de benzopyrane substitués, des stéréoisomères et des sels pharmaceutiquement acceptables desdits composés, ainsi que des procédés appropriés pour les préparer. Les composés de la présente invention s'utilisent comme agonistes du récepteur .beta. des oestrogènes. De tels agonistes s'utilisent dans le traitement d'affections induites par le récepteur .beta. des oestrogènes, telles que le cancer de la prostate ou l'hyperplasie prostatique bénigne (HPB).

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