Heterocyclic n-aryl carboxamides as cytokine inhibitors

Details Heterocyclic n-aryl carboxamides as cytokine inhibitors Heterocyclic n-aryl carboxamides as cytokine inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/404 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2518774

Disclosed are compounds of formula (I) where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

L'invention concerne des composés de formule générale (I) dans laquelle Ar¿1?, X, Y, Q, W, R?3¿, R?4¿, R?5¿, R?6¿ et R?y¿ ont la signification indiquée dans la description. Ces composés inhibent la production de cytokines impliquées dans des processus inflammatoires et s'avèrent ainsi utiles pour le traitement de maladies et d'états pathologiques impliquant une inflammation de type maladie inflammatoire chronique. L'invention concerne également des procédés de préparation desdits composés et des compositions pharmaceutiques comprenant ceux-ci.

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