Heterocyclic-substituted alkyl amide acat inhibitors

Details Heterocyclic-substituted alkyl amide acat inhibitors Heterocyclic-substituted alkyl amide acat inhibitors

C - Chemistry, Metallurgy

07

D

C07D 257/04 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) C07D 231/12 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 249/04 (2006.01) C07D 261/08 (2006.01) C07D 271/06 (2006.01) C07D 271/10 (2006.01) C07D 277/22 (2006.01) C07D 277/30 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2155104

Pharmaceutically useful compounds having ACAT inhibitory activity of formula (I), wherein n is 0, 1 or 2, for X other than tetrazole and n = 2 then R2 = R3 = H; R1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having from one to 18 carbon atoms; R2 and R3 are hydrogen, halo, hydroxy, alkyl, alkenyl, cycloalkyl, phenyl, substituted phenyl, a heteroaryl, or form a spiroalkyl group; X is a heteromonocyclic 5-membered ring containing one to four heteroatoms, said heteroatoms being nitrogen, oxygen or sulfur, and combination thereof; and R4 is a hydrocarbon group having from one to 20 carbon atoms are described as well as methods of their manufacture.

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