Heterologous production of polyketides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/61 (2006.01) C12N 1/21 (2006.01) C12N 9/90 (2006.01) C12P 11/00 (2006.01) C12P 19/62 (2006.01)

Patent

CA 2388422

Recombinant host cells that comprise recombinant DNA expression vectors that drive expression of a product and a precursor for biosynthesis of that product can be used to produce useful products such as polyketides in host cells that do not naturally produce the product or produce the product or precursor at low levels due to the absence of the precursor or the presence of the precursor in rate limiting amounts.

Selon l'invention, des cellules hôtes recombinantes comprenant des vecteurs d'expression d'ADN induisant l'expression d'un produit, et un précurseur servant à la biosynthèse dudit produit peuvent être utilisés pour obtenir des produits utiles, tels que des polycétides, dans des cellules hôtes ne produisant pas naturellement le produit, ou produisant le produit ou le précurseur à de faibles niveaux, en raison de l'absence du précurseur ou de la présence de ce dernier dans des quantités cinétiquement limitantes.

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