C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) A61K 35/74 (2006.01) A61K 39/102 (2006.01) C12N 15/31 (2006.01) C12N 15/64 (2006.01)
Patent
CA 2714292
The invention relates to Pasteurella multocida mutants capable of providing heterologous protection against infection caused by virulent P. multocida. Said mutants are defective in fur ompH and fur ompH galE genes. The invention relates to Pasteurella multocida bacteria vaccine compositions containing fur ompH double mutants and fur ompH galE triple mutants obtained from P. multocida, or an extract of iron-regulated outer-membrane proteins (IROMPs) obtained from said mutants, and to an excipient and/or pharmaceutically acceptable adjuvants.
La invención se refiere a mutantes de Pasteurella multocida capaces de conferir protección heteróloga frente a la infección producida por P. multocida virulenta. Estos mutantes son defectivos en los genes fur ompH y fur ompH galE. La presente invención se refiere a composiciones de vacuna contra la bacteria Pasteurella multocida, que comprenden dobles mutantes fur ompH y mutantes triples fur ompH galE obtenidos a partir de P. multocida, o un extracto de proteínas de membrana externa reguladas por hierro (IROMPs) obtenidas a partir de dichos mutantes, y un vehículo y/o adyuvantes farmacéuticamente aceptables.
Badiola Saiz
Barbe Garcia Jorge
Bosch Gallego Montserrat
Garrido Ocana Ma Elena
Llagostera Casas Montserrat
Gowling Lafleur Henderson Llp
Universitat Autonoma de Barcelona
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