Heterovesicular liposomes

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/127 (2006.01)

Patent

CA 2078666

Disclosed are heterovesicular liposomes containing different biological compositions (14, 14a) each encapsulated in sepa- rate chambers of the liposomes, having defined size distribution, adjustable internal chamber size and number, methods of mak- ing them and treatment of patients with them. The preparation process includes the addition of composition to first lipid compo- nent in the vial to obtain an emulsion, the addition of composition to second lipid component in the vial to obtain a second emulsion and mixing these emulsions to form a chimeric emulsion.

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