Hexahydro-7-1h-azepin-2-yl-haxanoic acid derivatives as...

C - Chemistry – Metallurgy – 07 – D

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C07D 233/12 (2006.01) A61K 31/55 (2006.01) A61P 29/00 (2006.01) C07D 223/10 (2006.01) C07D 223/12 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2415851

Iminoazepinyl Hexanoic Acid derivatives of formula (I) as well as pharmaceutically acceptable salts and derivatives thereof useful in the inhibition of the inducible isoform of nitric oxide synthase for the treatment of arthritis, osteoarthritis, rheumatism, inflammation are disclosed.

L'invention concerne des dérivés d'acide imino-azépinyle hexanoïque représentés par la formule (I), ainsi que des sels pharmaceutiquement acceptables et leurs dérivés utiles pour inhiber l'isoforme inductible d'oxyde nitrique synthase dans le traitement de l'arthrite, de l'ostéo-arthrite, des rhumatismes et de l'inflammation.

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