High-density ion transport measurement biochip devices and...

G - Physics – 01 – N

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G01N 15/06 (2006.01)

Patent

CA 2554376

The present invention provides novel biochips, biochip-based devices, and device configurations that can be used for ion transport measurement. The chips, devices, and designs of the present invention are particularly suited to high-throughput assays such as compound screening assays using patch clamping techniques. The invention includes high-density biochips made by novel methods and methods of making high density biochips, and also provides novel upper chamber configurations and fluidics designs for upper chambers of ion transport measurement devices that can be used in high throughput patch clamp assays. The present invention also includes methods of using ion transport measuring chips and devices of the present invention.

La présente invention concerne de nouvelles biopuces, des dispositifs contenant des biopuces, et des configurations de dispositifs qui peuvent être utilisés dans la mesure de transport ionique. Les puces, les dispositifs et les modèles de cette invention sont particulièrement appropriés à des dosages à rendement élevé, tels que des dosages de criblage de composés utilisant des techniques de type <= patch clamp >=. Cette invention a aussi trait à des biopuces à densité élevée élaborées à partir de nouveaux procédés et à des procédés de fabrication de biopuces à densité élevée, ainsi qu'à de nouvelles configurations de chambres supérieures et à des modèles fluidiques pour chambres supérieures de dispositifs de mesure de transport ionique qui peuvent être utilisés dans des dosages de type <= patch clamp >= de rendement élevé. Ladite invention a également pour objet des procédés d'utilisation de puces de mesure du transport ionique et des dispositifs de la présente invention.

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