High titer recombinant influenza viruses for vaccines

Details High titer recombinant influenza viruses for vaccines High titer recombinant influenza viruses for vaccines

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/145 (2006.01) A61P 37/04 (2006.01) C07K 14/11 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/44 (2006.01) C40B 40/08 (2006.01)

Patent

CA 2647985

The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes at least five internal genes from an influenza virus isolate that replicates to high titers in embryonated chicken eggs or MDCK cells.

L'invention concerne une composition utile pour préparer des virus de la grippe à haut titre, par exemple, en l'absence de virus auxiliaire, qui incluent au moins cinq gènes internes d'un isolat du virus de la grippe qui se réplique à hauts titres dans des AEufs de poule embryonnés ou des cellules MDCK.

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