Hla-dr antigen gene and its nucleotide sequence and its use

Details Hla-dr antigen gene and its nucleotide sequence and its use Hla-dr antigen gene and its nucleotide sequence and its use

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/74 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2049449

We have found a novel subtype DRw14c and sequenced the nucleotide sequence thereof. DRw14 associated genes can be genetically typed at the DNA level using DRB1-14c sequence specific oligonucleotide probes such as F142 and F144 of the invention. The present invention overcomes the disadvantages of serological typing and provides a reagent that determines a type of a HLA-DR antigen. More specifically, the invention provides an oligonucleotide probe capable of identifying subtypes of a HLA-DR antigen precisely and a reagent containing the oligonucleotide probe. Furthermore, the invention provides a method of detecting a novel HLA-DR antigen.

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