Homogeneous preparations of il-28 and il-29

Details Homogeneous preparations of il-28 and il-29 Homogeneous preparations of il-28 and il-29

C - Chemistry, Metallurgy

07

K

C07K 14/555 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) C07K 1/107 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2534907

Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.

L'invention concerne des préparations homogènes d'IL-28A, d'IL-28B et d'IL-29 produites par mutation d'un ou de plusieurs des résidus de cystéine dans les séquences polynucléotidiques codant pour les protéines matures. Les protéines mutantes de cystéine peuvent se lier à leur récepteur apparenté ou présenter une activité biologique. Un type d'activité biologique mis en évidence est une activité antivirale.

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