Homogeneous preparations of il-31

Details Homogeneous preparations of il-31 Homogeneous preparations of il-31

C - Chemistry, Metallurgy

07

K

C07K 14/52 (2006.01) A61K 38/19 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12N 15/24 (2006.01)

Patent

CA 2594502

Homogeneous preparations of human and murine IL-31 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity.

La présente invention se rapporte à des préparations homogènes d'IL-31 humaines et murines, qui ont été produites par la mutation d'un ou plusieurs des résidus cystéine contenus dans les séquences polynucléotidiques codant les protéines matures. Les protéines mutantes de cystéine peuvent soit se lier à leur récepteur parent soit présenter une activité biologique.

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