Hormone analogs with multiple ctp extensions

Details Hormone analogs with multiple ctp extensions Hormone analogs with multiple ctp extensions

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 47/48 (2006.01) C07K 14/575 (2006.01) C07K 14/59 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2120358

The invention provides peptide and protein pharmaceuticals with extended half- lives. The modified peptides and proteins of the invention contain at least two tandem extensions at their C-terminus comprising the carboxy terminal portion of human chorionic gonadotropin. These "CTP units" consist essentially of the native HCG-.beta. sequence from position 112,118 to position 145 or conservative modifications thereof.

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