Human atrial natriuretic peptide and gene coding for same

Details Human atrial natriuretic peptide and gene coding for same Human atrial natriuretic peptide and gene coding for same

C - Chemistry, Metallurgy

12

N

530/13, 195/1.2,

C12N 15/16 (2006.01) A61K 38/22 (2006.01) C07K 14/58 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340453

Disclosed is a DNA fragment comprising a base sequence coding for a peptide occurring in human atrium cordis and having diuretic action or a precursor of, the peptide, plasmids containing the DNA fragment, micro-organisms transformed with the plasmid, and a process for production of the peptide using the transformant. Also disclosed is a new peptide consisting of 126 amino acids occurring in human atrium cordis and a precursor thereof. The peptide has notable diuretic action and hypotensive or antihypertensive actions.

483450

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