C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 48/00 (2006.01) C07K 14/71 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/64 (2006.01) C12N 15/864 (2006.01)
Patent
CA 2358094
The present invention relates generally to the fields of gene therapy. More particularly, it concerns gene transfer using adeno-associated virus and methods of increasing transcription and promoting replication of transgenes. The present invention shows that AAV requires human fibroblast growth factor receptor 1 (FGFR1) as a co-receptor for successful viral entry into the host cell. Methods and compositions for exploiting this finding in AAV vector- mediated gene therapy are disclosed.
La présente invention concerne en général la thérapie génique, et plus particulièrement le transfert de gènes à l'aide de virus associés aux adénovirus, ainsi que des procédés visant à accroître la transcription et faciliter la réplication des transgènes. Cette invention démontre que l'AAV a besoin du récepteur 1 humain du facteur de croissance des fibroblastes comme co-récepteur pour réussir la pénétration virale dans la cellule hôte. L'invention concerne également des procédés et des compositions permettant d'exploiter cette recherche en thérapie génique induite par le vecteur AAV.
Dwarki Varavani
Hansen Jonathan
Mah Cathryn
Qing Keyun
Srivastava Arun
Advanced Research And Technology Institute Inc.
Dwarki Varavani
Goudreau Gage Dubuc
Hansen Jonathan
Mah Cathryn
LandOfFree
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