Human g-protein coupled receptor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2383177

The present invention relates to the IGS3 G-protein coupled receptor family, and to polynucleotides encoding said IGS3 proteins. The invention also relates to inhibiting or activating the action of such polynucleotides and polypeptides, to a vector containing said polynucleotides, a host cell containing such vector and non-human transgenic animals where the IGS3-gene is either overexpressed, misexpressed, underexpressed or suppressed (knock-out animals). The invention further relates to a method for screening compounds capable to act as an agonist or an antagonist of said G-protein coupled receptor family IGS3 and the use of IGS3 polypeptides and polynucleotides and agonists or antagonists to the IGS3 receptor family in the treatment of a broad range of disorders and diagnostic assays for such conditions.

La présente invention concerne la famille des récepteurs couplés à la protéine G, IGS3, et les polynucléotides codant ces protéines IGS3. Cette invention concerne également l'inhibition ou l'activation l'action de ces polynucléotides et polypeptides, des vecteurs renfermant ces polynucléotides, une cellule hôte renfermant ce vecteur, ainsi que des animaux transgéniques non humains chez lesquels le gène IGS3 est surexprimé, mal exprimé, sousexprimé, ou supprimé (animaux à gène inactivé). Cette invention concerne par ailleurs un procédé servant à cribler des composés pouvant agir comme antagonistes ou un antagoniste de ladite famille des récepteurs couplés à la protéine G IGS3, et à utiliser ces polypeptides et ces polynucléotides IGS3, et des agonistes ou des antagonistes de la famille des récepteurs IGS3, pour le traitement d'un large éventail de troubles et des essais diagnostics pour les conditions précitées.

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