Human gtp binding protein gamma-3

Details Human gtp binding protein gamma-3 Human gtp binding protein gamma-3

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2264542

The present invention provides a polynucleotide which identifies and encodes a human GTP binding protein gamma-3 (HGPG) and HGPG itself. The invention provides for genetically engineered expression vectors, host cells containing the vector and a method for producing HGPG. The invention also provides a method for identifying pharmaceutical compositions inhibiting the expression and activity of HGPG and for the use of such compositions for the treatment of cancer. The invention also provides diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HGPG or anti-HGPG antibodies which specifically bind to HGPG in normal or diseased tissues.

L'invention concerne un polynucléotide qui identifie et code pour une protéine humaine gamma 3 (HGPG) de fixation de la GTP et la HGPG elle-même. Elle se rapporte à des vecteurs d'expression génétiquement modifiés, à des cellules hôtes contenant le vecteur, à un procédé de production HGPG, à un procédé d'identification de compositions pharmaceutiques inhibant l'expression et l'activité de HGPG et à l'utilisation desdites compositions pour le traitement du cancer. Elle concerne des méthodes diagnostiques dans lesquelles on utilise ledit polynucléotide pour l'hybrider aux produits de transcription codant HGPG ou des anticorps anti-HGPG qui se lient spécifiquement à HGPG dans des tissus normaux ou malades.

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