C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 15/00 (2006.01) C12N 15/66 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2341308
The invention provides isolated nucleic acid compounds encoding polypeptides and fragments thereof, said polypeptides being related to the human TGF.beta. latent binding protein (hLTBP) family. This invention also provides vectors and transformed heterologous host cells for expressing said polypeptides, a method of using said nucleic acids and polypeptides for inhibiting TGF.beta. dependent activities in vitro or in vivo, as well as pharmaceutical compositions comprising said nucleic acids or polypeptides. Also provided are assays used to identify compounds which bind to said polypeptides.
L'invention concerne des composés d'acides nucléiques isolés codant des polypeptides et leurs fragments, lesdits polypeptides étant apparentés à la famille de la protéine de fixation latente à TGF.beta. humain (hLTBP). Elle concerne également des vecteurs et des cellules hôtes hétérologues transformées servant à exprimer lesdits polypeptides, un procédé d'utilisation desdits acides nucléiques et polypeptides afin d'inhiber des activités dépendantes de TGF.beta. in vitro ou in vivo, ainsi que des compositions pharmaceutiques contenant lesdits acides nucléiques ou polypeptides. Elle concerne également des méthodes mises en application afin d'identifier des composés se fixant audits polypeptides.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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