C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/15.06, 167/1
C07K 14/475 (2006.01) A61K 38/18 (2006.01)
Patent
CA 2017237
ABSTRACT A human mammary cell growth inhibitor, and novel compositions comprising enhanced and purified concentrations thereof, inhibits the growth of human mammery cell. Inhibitor of the present invention purified by monoclonal antibody affinity chromatography comprises a thermolabile protein and has peaks of inhibitory activity at molecular weights of about 47,000 and about 63,000-67,000 as determined by SDS-PAGE. The inhibitory activity of the inhibitor is mammary cell specific, and is both calcium and dose-dependent. Increased production of the inhibitor can be induced by growth of inhibitior-escreting human mammary cells in low concentrations of calcium. The inhibitor can be used prophylactically to decrease the risk of breast cancer, to screen for the risk or presence of breast cancer, and as a terepeutic agent for the treatment of breast cancer,
Cody Robert L.
Ervin Paul R. Jr.
Wicha Max S.
Cody Robert L.
Ervin Paul R. Jr.
Smart & Biggar
The Regents Of The University Of Michigan
Wicha Max S.
LandOfFree
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