Human monoclonal antibodies to activin receptor-like kinase-1

Details Human monoclonal antibodies to activin receptor-like kinase-1 Human monoclonal antibodies to activin receptor-like kinase-1

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/40 (2006.01)

Patent

CA 2621371

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular doman (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK- 1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of makind human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

L'invention concerne des anticorps notamment des anticorps humains et des fractions de liaison à l'antigène de ceux-ci qui se lient au domaine extracellulaire (ECD) d'une kinase-1 de type récepteur d'activine (ALK-1) et qui fonctionne de manière à annuler la voie de signalisation ALK-1/TGF-bêta-1/Smad1. L'invention concerne également des immunoglobines à chaînes lourde et légère dérivées d'anticorps anti-ALK-1 humains et des molécules d'acides nucléiques codant ces immunoglobines. Cette invention concerne enfin des procédés de production d'anticorps anti-ALK-1 humains, des compositions contenant cet anticorps et des procédés utilisant ces anticorps et ces compositions, ainsi que des animaux ou des plantes transgéniques contenant des molécules d'acides nucléiques de cette invention.

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