Human monoclonal antibodies to cancer cells

C - Chemistry – Metallurgy – 12 – N

Patent

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167/37, 195/1.10

C12N 5/00 (2006.01) A61K 39/395 (2006.01) C07K 16/30 (2006.01) G01N 33/577 (2006.01)

Patent

CA 1242401

Abstract of the Disclosure Hybridomas which produce human monoclonal anti- bodies are disclosed. The hybridomas are formed by fusing lymphocytes from individuals with various cancers to an immortal cell line, such as a myeloma, from e.g., a human cell line, or a mouse cell line. The human monoclonal antibodies produced by these hybridomas recognize certain cell surface and intracellular antigens on normal and malig- nant cells. These human monoclonal antibodies are used in the diagnosis of cancer.

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