C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2389203
The present invention provides purified secretory polynucleotides (sptm). Also encompassed are the polypeptides (SPTM) encoded by sptm. The invention also provides for the use of sptm, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing sptm for the expression of SPTM. The invention additionally provides for the use of isolated and purified SPTM to induce antibodies and to screen libraries of compounds and the use of anti-SPTM antibodies in diagnostic assays. Also provided are microarrays containing sptm and methods of use.
L'invention concerne des polynucléotides sécrétoires purifiés (SPTM), ainsi que des polypeptides (SPTM) codés par les SPTM. L'invention concerne également l'utilisation de SPTM, ou de compléments, ou d'oligonucléotides, ou de fragments de ces derniers dans des jeux ordonnés d'échantillons de diagnostic. L'invention concerne en outre des vecteurs et des cellules hôtes contenant des SPTM pour l'expression de SPTM. L'invention concerne aussi l'utilisation de SPTM isolés et purifiés pour induire des anticorps et pour examiner des bibliothèques de composés, et l'utilisation d'anticorps SPTM dans des jeux ordonnés d'échantillons de diagnostic. L'invention concerne enfin des jeux ordonnés de microéchantillons contenant des SPTM et des procédés d'utilisation.
Amshey Stefan
Banville Steven C.
Bratcher Shawn R.
Chalup Michael S.
Chen Wensheng
Incyte Genomics Inc.
Smart & Biggar
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