Human tissue plasminogen activator

C - Chemistry – Metallurgy – 12 – N

Patent

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195/1.22, 195/1.

C12N 15/00 (2006.01) C12N 1/20 (2006.01) C12N 5/00 (2006.01) C12N 9/06 (2006.01) C12N 9/48 (2006.01) C12N 9/64 (2006.01) C12N 9/72 (2006.01) C12N 15/71 (2006.01) C12P 19/34 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1293211

ABSTRACT OF DISCLOSURE Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant techniques. This invention thus enables production of t-PA free of contaminants associated with it in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.

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