Humanized antibody and process for preparing same

Details Humanized antibody and process for preparing same Humanized antibody and process for preparing same

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/08 (2006.01) C07K 16/46 (2006.01) C12N 1/21 (2006.01) C12N 15/00 (2006.01) C12N 15/70 (2006.01)

Patent

CA 2492671

A humanized antibody is produced by process comprising the steps of: (a) selecting a specificity determining residue (SDR) of the complementarity determining region (CDR) of murine monoclonal antibody heavy chain and light chain variable regions; and (b) grafting said SDR to at least one of the corresponding amino acid sequences in human antibody variable regions.

Un anticorps humanisé est produit conformément au procédé comportant les étapes consistant à: (a) sélectionner un résidu déterminant une spécificité (SDR) de la région déterminant la complémentarité (CDR) des régions variables de chaîne lourde et de chaîne légère d'un anticorps monoclonal de muridés; et (b) greffer ledit résidu SDR sur l'une des séquences d'acides aminés correspondantes des régions variables de l'anticorps humain.

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