C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.22, 167/10
C12N 15/62 (2006.01) A61K 38/49 (2006.01) C07K 19/00 (2006.01) C12N 9/72 (2006.01) C12N 15/10 (2006.01) C12N 15/58 (2006.01) C12N 15/79 (2006.01) C12P 21/02 (2006.01)
Patent
CA 1341479
Novel single-chain hybrid plasminogen activators having an amino acid sequence composed of at least two subsequences corresponding in amino acid identity and number to subsequences of human t-PA and of human u-PA, and mutants thereof in which at least one of the N-glycosylation sites is modified such that glycosylation cannot take place at these sites exhibit valuable pharmacological properties. The hybrid plasminogen activators are produced by recombinant DNA technology.
553406
Alkan Sefik
Asselbergs Fredericus Alphonsus Maria
Chaudhuri Bhabatosh
Heim Jutta
Meyhack Bernd
Alkan Sefik
Asselbergs Fredericus Alphonsus Maria
Chaudhuri Bhabatosh
Fetherstonhaugh & Co.
Heim Jutta
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