Hydantoin derivatives

Details Hydantoin derivatives Hydantoin derivatives

C - Chemistry, Metallurgy

07

D

167/207, 260/300

C07D 405/12 (2006.01) A61K 31/415 (2006.01) C07D 209/30 (2006.01) C07D 213/70 (2006.01) C07D 235/28 (2006.01) C07D 249/18 (2006.01) C07D 261/20 (2006.01) C07D 275/04 (2006.01) C07D 277/54 (2006.01) C07D 277/80 (2006.01) C07D 307/64 (2006.01) C07D 307/82 (2006.01) C07D 311/14 (2006.01) C07D 311/24 (2006.01) C07D 333/34 (2006.01) C07D 333/62 (2006.01) C07D 333/72 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1338866

The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel intermediate compounds in the synthesis of said hydantoin derivatives. The present invention is based on the selection of a hydantoin which is bonded by a sulfonyl group to various substituents at the 1-position of the hydantoin skeleton. The compounds of the present invention have a strong inhibitory activity against aldose reductase. These compounds are extremely useful for the treatment and/or prevention of various forms of diabetic complications based on the accumulation of polyol metabolites.

609100

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