Hydrazide and alkoxyamide angiogenesis inhibitors

Details Hydrazide and alkoxyamide angiogenesis inhibitors Hydrazide and alkoxyamide angiogenesis inhibitors

C - Chemistry, Metallurgy

07

C

C07C 243/28 (2006.01) A61K 31/165 (2006.01) A61K 31/175 (2006.01) A61K 31/18 (2006.01) A61K 31/435 (2006.01) A61K 31/50 (2006.01) C07C 239/20 (2006.01) C07C 243/34 (2006.01) C07C 243/38 (2006.01) C07C 251/86 (2006.01) C07C 255/42 (2006.01) C07C 255/66 (2006.01) C07C 259/06 (2006.01) C07C 281/02 (2006.01) C07C 281/06 (2006.01) C07C 311/38 (2006.01) C07C 321/14 (2006.01) C07C 323/41 (2006.01) C07C 323/60 (2006.01) C07C 323/62 (2006.01) C07D 207/416 (2006.01) C07D 207/50 (2006.01) C07D 209/20 (2006.01) C07D 21

Patent

CA 2406442

Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.

Dans cette invention, les composés représentés par la formule (I) sont des inhibiteurs d'aminopeptidase méthionine de type 2 (MetAP2), utilisés pour inhiber l'angiogenèse. Cette invention concerne en outre des compositions inhibitrices de MetAP2 ainsi que des méthodes d'inhibition de l'angiogenèse chez un mammifère.

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