Hydrogel-driven drug dosage form

Details Hydrogel-driven drug dosage form Hydrogel-driven drug dosage form

A - Human Necessities

61

K

A61K 9/36 (2006.01) A61K 31/519 (2006.01) A61P 15/10 (2006.01)

Patent

CA 2395333

A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.

L'invention concerne une forme de dosage à libération contrôlée, possédant un noyau enrobé, ledit noyau comprenant une composition contenant un médicament et une composition gonflable à l'eau, chaque composition occupant des régions séparées dudit noyau. La composition contenant un médicament comprend un médicament à faible solubilité, et un agent d'entraînement de médicament. L'enrobage du noyau est imperméable à l'eau, insoluble dans l'eau, et possède au moins un orifice de distribution. L'invention concerne également une variété de formulations présentant des profils de libération de médicament spécifiques.

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