Hydropyridine derivatives having antithrombotic activity

Details Hydropyridine derivatives having antithrombotic activity Hydropyridine derivatives having antithrombotic activity

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/435 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01)

Patent

CA 2077695

The present invention relates to a series of new tetrahydrothieno[3,2-c]pyridine derivatives and furo and pyrrolo analogs of these derivatives, and provides processes for preparing these derivatives as well as methods and compositions using them for inhibiting blood platelet aggregation. More specifically, disclosed is a compound of formula (I): (See formula I) wherein, preferably: R1 represents a hydrogen atom, a methyl group, an ethyl group, a halogen atom, a methyl group substituted by at least one fluorine atom, a hydroxy group, a methoxy group, an ethoxy group, a methoxy group substituted by at least one fluorine atom, a methylthio group, a methylthio group substituted by at least one fluorine atom, a formyl group, an acetyl group, an acetyl group substituted by at least one fluorine atom, an alkoxycarbonyl group having from 2 to 4 carbon atoms, a carbamoyl group, a cyano group, a nitro group, a methanesulfonyl group, an ethanesulfonyl group, a methanesulfonyl group substituted by at least one fluorine atom, or a sulfamoyl group; R2 represents an alkanoyl group having from 2 to 6 carbon atoms, a substituted alkanoyl group which has from 2 to 6 carbon atoms and which is substituted by at least one fluorine atom, a cycloalkylcarbonyl group having from 4 to 7 carbon atoms, or a substituted cycloalkylcarbonyl group which is substituted by at least one fluorine atom; R3 represents a hydrogen atom, a hydroxy group, a methoxy group, an ethoxy group, a t-butoxy group, a methoxymethoxy group, an alkanoyloxymethoxy group in which the alkanoyl part has from 1 to 5 carbon atoms, a benzyloxy group, an alkanoyloxy group having from 1 to 12 carbon atoms, an alkenoyloxy group having 3 or 4 carbon atoms, a cycloalkylcarbonyloxy group having from 4 to 7 carbon atoms, a benzoyloxy group, an alkoxycarbonyloxy group having from 2 to 5 carbon atoms, a benzyloxycarbonyloxy group, a phthalidyloxy group, a (5-methyl-2-oxo-1,3- dioxolen-4-yl)methoxy group, a (5-phenyl-2-oxo-1,3- dioxolen-9-yl)methoxy group, an amino group or a t- butoxycarbonylamino group; Y represents an oxygen or sulfur atom; and n is 1 to 3.

Affiliated with

Also associated with

Rating

Hydropyridine derivatives having antithrombotic activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydropyridine derivatives having antithrombotic activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydropyridine derivatives having antithrombotic activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1845636