Hydroxamic acid derivative and pharmaceutical use thereof

Details Hydroxamic acid derivative and pharmaceutical use thereof Hydroxamic acid derivative and pharmaceutical use thereof

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07C 233/31 (2006.01) C07D 207/32 (2006.01) C07D 209/46 (2006.01) C07D 209/48 (2006.01) C07D 233/34 (2006.01) C07D 233/72 (2006.01) C07D 307/46 (2006.01) C07D 307/52 (2006.01) C07D 309/12 (2006.01) C07D 333/40 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 409/1

Patent

CA 2332946

Hydroxamic acid derivatives represented by general formula (I) or pharmacologically acceptable salts thereof; medicinal compositions containing the same and medicinal utilization thereof wherein each symbol has the meaning as defined in the specification. Because of having TNF-.alpha. production inhibitory effect, these derivatives or pharmacologically acceptable salts thereof are useful in preventing/treating autoimmune diseases and inflammatory diseases, for example, sepsis, MOF, rheumatoid arthritis, Crohn's disease, cachexia, myasthenia gravis, systemic lupus erythematosus, asthma, I type diabetes and psoriasis.

L'invention se rapporte à des dérivés d'acide hydroxamique représentés par la formule générale (I), à des sels pharmacologiquement acceptables de ces dérivés, à des compositions médicinales contenant de tels dérivés et à leur utilisation médicinale. Dans la formule (I), chaque symbole a la signification spécifiée dans la description de l'invention. En raison de leur effet inhibiteur vis à vis de la production de TNF-.alpha., ces dérivés ou leurs sels pharmacologiquement acceptables s'avèrent utiles pour prévenir/traiter les maladies auto-immunes et les maladies inflammatoires du type septicémie, MOF, polyarthrite rhumatoïde, maladie de Crohn, cachexie, myasthénie grave, lupus érythémateux disséminé, asthme, diabète insulino-dépendant et psoriasis.

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