Hydroxamic acids and acyl hydroxamines as naaladase inhibitors

Details Hydroxamic acids and acyl hydroxamines as naaladase inhibitors Hydroxamic acids and acyl hydroxamines as naaladase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/10 (2006.01) A61K 31/16 (2006.01) C07C 317/44 (2006.01) C07C 323/60 (2006.01)

Patent

CA 2446740

This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-.beta. activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.

L'invention concerne de nouveaux composés, des compositions pharmaceutiques et des kits de diagnostic comprenant ces composés ainsi que des procédés pour utiliser ces composés en tant qu'inhibiteurs de l'activité de l'enzyme NAALADase, détecter les maladies lors desquelles la teneur en NAALADase est modifiée, affecter l'activité neuronale, affecter l'activité de TGF-.beta., inhiber l'angiogenèse et traiter les anormalités de glutamate, la neuropathie, la douleur, les troubles compulsifs, les maladies de la prostate, les cancers et le glaucome.

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