C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/437 (2006.01) A61K 31/4375 (2006.01) C07D 471/16 (2006.01)
Patent
CA 2598639
Certain imidazonaphthyridines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-.alpha. biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
L'invention concerne certaines imidazonaphthyridines présentant un substituant hydroxyméthyle ou hydroxyéthyle à la position 2, des compositions pharmaceutiques contenant lesdits composés, des intermédiaires, des procédés de préparation et des procédés d'utilisation desdits composés en tant qu'immunomodulateurs, afin d'induire préférentiellement une biosynthèse d'IFN-a chez des animaux, ainsi que dans le traitement de maladies, notamment de maladies virales et néoplasiques.
Griesgraber George W.
Heppner Philip D.
Kshirsagar Tushar A.
Langer Scott E.
Lindstrom Kyle J.
Coley Pharmaceutical Group Inc.
Smart & Biggar
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