Hydroxyamino-eburnane derivatives and a process for the...

Details Hydroxyamino-eburnane derivatives and a process for the... Hydroxyamino-eburnane derivatives and a process for the...

C - Chemistry, Metallurgy

07

D

260/272

C07D 459/00 (2006.01)

Patent

CA 1195978

Abstract of the Disclosure The invention relates to novel indoloquinolisines of formula Image wherein A stands for hydrogen or a C-N bond and when A is a C-N bond then the nitrogen atom bears a positive charge balanced by a negatively charged acid residue X-, Y stands for hydrogen or a group of the formula -CH2CH(COORl)2, R1 and R2 both stand for C1-6 alkyl groups, R3 is the same as R1 or, when Y and A are both hydrogen atoms, R3 can also be hydrogen. The novel indolo- quinolisines are valuable intermediates in the preparation of novel hydroxy- amino-eburnane compounds which display pharmaceutical activity as peripheral vasodilating activity and which can be converted into other compounds, e.g. vincamine and apovincamine compounds of therapeutic value.

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