C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2542904
The present invention provides nucleobase oligomers and oligomer complexes that inhibit expression of an IAP polypeptide, and methods for using them to induce apoptosis in a cell. The nucleobase oligomers and oligomer complexes of the present invention may also be used to form pharmaceutical compositions. The invention also features methods for enhancing apoptosis in a cell by administering a nucleobase oligomer or oligomer complex of the invention in combination with a chemotherapeutic or chemosensitizing agent.
L'invention porte sur des oligomères de nucléobases IAP, sur des complexes oligomères, inhibant l'expression de polypeptides IAP et sur leurs méthodes d'utilisation pour induire l'apoptose de cellules. Lesdits oligomères et complexes oligomères peuvent entrer dans la composition de préparations pharmaceutiques . L'invention porte également sur des procédés d'accroissement de l'apoptose cellulaire par administration de tels oligomères ou complexes d'oligomères, associé à un agent chimiothérapeutique ou chimiosensibilateur.
Lacasse Eric
Mcmanus Daniel
Aegera Therapeutics Inc.
Ridout & Maybee Llp
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