Identification of non-small cell lung carcinoma (nsclc)...

A - Human Necessities – 61 – K

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A61K 31/506 (2006.01) A61K 31/4045 (2006.01) A61P 35/00 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2617201

The invention discloses a previously unidentified subset of mammalian non- small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFR.alpha.) is expressed and is driving the disease, and provided methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFR.alpha. is expressed, and for identifying a NSCLC tumor that is likely to respond to a PDGFR.alpha.-inhibiting therapeutic. The invention also provides methods for inhibiting the progression of a mammalian NSCLC tumor in which PDGFR.alpha. is expressed, and for determining whether a compound inhibits the progression of a PDGFR.alpha.- expressing mammalian NSCLC tumor.

La présente invention concerne un sous-ensemble jusqu'alors non identifié de carcinomes bronchopulmonaires 'non à petites cellules'' de mammifère (NSCLC) dans lequel le récepteur alpha du facteur de croissance dérivé des plaquettes (PDGFRa) est exprimé et commande la maladie ainsi que des méthodes permettant d'identifier une tumeur NSCLC de mammifère qui appartient à un sous-ensemble de tumeurs NSCLC dans lequel PDGFRa est exprimé et permettant d'identifier une tumeur NSCLC qui est susceptible de réagir à une thérapie inhibant PDGFRa. Cette invention porte également sur des méthodes permettant d'inhiber l'évolution d'une tumeur NSCLC de mammifère dans laquelle PDGFRa est exprimé et de déterminer si un composé inhibe l'évolution d'un tumeur NSCLC de mammifère dans laquelle est exprimé PDGFRa.

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