Identification of novel mechanisms of drug resistance

Details Identification of novel mechanisms of drug resistance Identification of novel mechanisms of drug resistance

G - Physics

01

N

G01N 33/50 (2006.01) C12N 15/10 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2374918

The present invention provides methods of identifying candidate agents that bind to and regulate cellular proteins involved in multi-drug resistance (MDR). As outlined herein, there are two basic types of screens that can be done: 1) screens for compounds that confer a multridrug resistance phenotype; and, 2) screens for compounds that ameliorate a multridrug resistance phenotype. Once target molecules have been identified, as is outlined herein with the identification of XAPC7 and Zeta, and, when inhibited by the RGP8.5 peptide confer multidrug resistance, the XAPC7 and Zeta molecules can be used in screens for candidate drugs that bind to them and modulate their activity.

La présente invention concerne, de façon générale, des méthodes de criblage appliquées à des médicaments qui se lient à et/ou régulent des protéines cellulaires impliquées dans la résistance aux médicaments, notamment la résistance des cellules tumorales aux agents chimiothérapeutiques.

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