C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) G01N 33/564 (2006.01)
Patent
CA 2682774
The disclosure provides methods and compositions useful for treating autoimmune diseases and disorders. For example, the disclosure demonstrates that hypergammaglobulinemia and subsequent accelerated kidney disease can be suppressed by Ig minigene-induced CD8+ T cells that make CD4+ T cells hyporesponsive to antigenic stimulation, thus causing inhibition of renal disease and subsequent increased survival.
L'invention concerne des procédés et des compositions servant à traiter des maladies et des troubles auto-immuns. L'invention permet par exemple de démontrer qu'une hypergammaglobulinémie et qu'une maladie rénale accélérée qui en découle peuvent être supprimées par des cellules CD8+ T induites par des mini-gènes, ces cellules produisant des cellules CD4+ T hyporéactives par rapport à une stimulation antigénique, ce qui permet d'inhiber une maladie rénale pour une survie subséquente accrue.
Ferrera Francesca
Filaci Gilberto
Hahn Bevra H.
Indiveri Francesco
La Cava Antonio
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Regents Of The University Of California
Universita Degli Studi Di Genova
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