Ikaros isoforms and mutants

Details Ikaros isoforms and mutants Ikaros isoforms and mutants

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2349417

Specific Ikaros mutations, as well as the correlation of the presence of the specific Ikaros mutations and other wild-type non-DNA binding Ikaros isoforms with lymphoid cell abnormality is provided in the invention. Methods for detecting and treating lymphoid cell abnormality, including hematologic malignancy, are also provided.

L'invention concerne des mutations d'Ikaros spécifiques ainsi que la corrélation entre, d'une part, la présence de mutations d'Ikaros spécifiques et d'autres isoformes d'Ikaros de type sauvage ne se liant pas à l'ADN et, d'autre part, une anormalité de la cellule lymphoïde. L'invention concerne également des méthodes de détection et de traitement d'une anormalité de la cellule lymphoïde, notamment une malignité hématologique.

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