Il-15 antigen arrays and uses thereof

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2590778

The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-15 protein, an IL-15 mutein or an IL-15 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL- 15 protein, IL-15 mutein or at least one IL-15 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory and chronic autoimmune diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

La présente invention concerne les domaines de la biologie moléculaire, la virologie, l'immunologie et la médecine. Cette invention porte sur une composition comprenant un jeu d'antigènes ordonnés et répétitifs, dans lequel l'antigène est une protéine IL-15, une mutéine IL-15 ou un fragment IL-15. L'invention porte, plus spécifiquement, sur une composition comprenant une particule de type virus, et au moins une protéine IL-15, une mutéine IL-15 ou au moins un fragment IL-15 lié à celle-ci. L'invention porte, d'autre part, sur un procédé de production de la composition. Les compositions de l'invention sont utiles dans la fabrication de vaccins en vue de traiter des maladies inflammatoires et autoimmunes chroniques. La composition de l'invention induit efficacement les réponses immunes, notamment les réponses d'anticorps. De plus, les compositions de l'invention sont particulièrement utiles pour induire efficacement les réponses immunes autospécifiques dans le contexte indiqué.

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