Il-17 receptor a antigen binding proteins

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2663537

The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands. The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and antibodies that bind thereto. Aspects of the invention also include antibodies that compete for binding with the IL-17RA neutralizing antibodies described herein.

La présente invention concerne des protéines de liaison à l'antigène du récepteur A de l'IL-17 (IL-17RA ou IL-17R) telles que des anticorps, des séquences polynucléotidiques codant pour lesdites protéines de liaison à l'antigène, ainsi que des compositions et des procédés de diagnostic et de traitement de maladies induites par l'activation du récepteur A de l'IL-17 par un ou plusieurs ligands de l'IL-17. La présente invention concerne l'identification de déterminants neutralisants sur le récepteur A de l'IL-17 (IL-17RA ou IL-17R) et des anticorps qui se lient à eux. L'invention concerne également des anticorps qui entrent en compétition pour la liaison avec les anticorps neutralisants de l'IL-17RA décrits ici.

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