Il-1a immunization induces autoantibodies protective against...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/20 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 47/48 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2652274

Immunization of a mammal with IL-l.alpha., which causes the mammal to generate IL-l.alpha. autoantibodies, can be used to reduce the risk and severity of, or to reduce progression of, an atherosclerosis-related disease in the mammal. Progression of atherosclerosis-related diseases such as peripheral ischemic heart disease, coronary artery disease, cerebrovascular disease, and peripheral arterial disease can be reduced using this treatment.

La présente invention concerne l'immunisation d'un mammifère à l'aide de l'IL-l.alpha., laquelle immunisation entraîne chez le mammifère la génération d'auto-anticorps IL-l.alpha. et peut être utilisée pour réduire le risque et la gravité d'une maladie liée à l'athérosclérose chez le mammifère, ou en réduire la progression. La progression de maladies liées à l'athérosclérose telles qu'une insuffisance cardiaque ischémique périphérique, une coronaropathie, une maladie cérébrovasculaire, et une maladie artérielle périphérique, peut être réduite grâce à ce traitement.

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